*equal contribution #co-corresponding author Shao lab members
Structures of human organellar SPFH protein complexes.
Gao J, Sherpa D, Kupko N, and Shao S. (2025) preprint doi: 10.1101/2025.04.21.649849.
Publications
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
McKenna MJ, Kraus F, Coelho JPL, Vasandani M, Zhang J, Adams BM, Paulo J, Harper JW, and Shao S. (2025) PMID: 40203102.
Mechanism of ASF1 engagement by CDAN1.
Sedor SF and Shao S. (2025) PMID: 40091041. preprint doi: . PMID: 39149339.
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Nardone C*, Gao J*, Seo H, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi N, Fulciniti M, Greenberg ME, Shao S#, Elledge SJ#, and Gu X#. (2025) preprint doi: . PMID: 40027645.
Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation.
Bridgers JB*, Carlström A*, Sherpa D*, Couvillion MT, Rovšnik U, Gao J, Wan B, Shao S#, Ott M#, and Churchman LS#. (2025) preprint doi: . PMID: 39896557.
Structure of the TXNL1-bound proteasome.
Gao J*, Nardone C*, Yip MCJ*, Chino H, Gu X, Mirman Z, Rale MJ, Paulo JA, Elledge SJ#, and Shao S#. (2024) preprint doi: .
A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion.
Richmond-Buccola D, Hobbs SJ, Garcia JM, Toyoda H, Gao J, Shao S, Lee ASY, and Kranzusch PJ. (2024) PMID: 38917809.
The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center.
Coelho JPL*, Yip MCJ*, Oltion K, Taunton J, and Shao S. (2024) PMID: 38172604.
The endoplasmic reticulum and the fidelity of nascent protein localization.
McKenna MJ and Shao S. (2023) PMID: 36041782.
ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.
McKenna MJ, Adams BM, Chu V, Paulo JA, and Shao S. (2022) PMID: 36283413.
Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes.
Juette MF*, Carelli JD*, Rundlet EJ*, Brown A, Shao S, Ferguson A, Wasserman MR, Holm M, Taunton J#, and Blanchard SC#. (2022) PMID: 36264623.
Mechanism of client selection by the protein quality control factor UBE2O.
Yip MCJ*, Sedor SF*, and Shao S. (2022) PMID: 35915257.
Cryo-EM structure of an active bacterial TIR-STING filament complex.
Morehouse BR, Yip MCJ, Keszei AFA, McNamara-Bordewick NK, Shao S#, and Kranzusch PJ#. (2022) PMID: 35869168.
Structural insights into metazoan pretargeting GET complexes.
Keszei AFA, Yip MCJ, Hsieh TC, and Shao S. (2021) PMID: 34887561.
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.
Tal N*, Morehouse BR*, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ#, and Sorek R#. (2021) PMID: 34644530.
Discovery of C13-aminobenzoyl cycloheximide derivatives that potently inhibit translation elongation.
Koga Y, Hoang EM, Park Y, Keszei AFA, Murray J, Shao S#, and Liau BB#. (2021) PMID: 34403584.
Detecting and rescuing stalled ribosomes.
The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.STING cyclic dinucleotide sensing originated in bacteria.
Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, and Kranzusch PJ. (2020) PMID: 32877915.
CBASS immunity uses CARF-related effectors to sense 3'-5'- and 2'-5'-linked cyclic oligonucleotide signals and protect bacteria from phage infection.
Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, and Kranzusch PJ. (2020) PMID: 32544385.
ELAC1 repairs tRNAs cleaved during ribosome-associated quality control.TTC5 mediates autoregulation of tubulin via mRNA degradation.
Lin Z, Gasic I, Chandrasekaran V, Peters N, Shao S, Mitchison TJ, and Hegde RS. (2020) PMID: 31727855.
Mechanism of ribosome stalling during translation of a poly(A) tail.
Chandrasekaran V*, Juszkiewicz S*, Choi J, Puglisi JD, Brown A, Shao S, Ramakrishnan V, and Hegde RS. (2019) PMID: 31768042.
Mechanism for recycling tRNAs on stalled ribosomes.Activation of GCN2 by the ribosomal P-stalk.
Inglis AJ, Masson GR, Shao S, Perisic O, McLaughlin SH, Hegde RS, and Williams RL. (2019) PMID: 30804176.
Structures of translationally inactive mammalian ribosomes.
Ribosomes and cryo-EM: a duet.
In vitro reconstitution of translational arrest pathways.
Mechanistic basis for a molecular triage reaction. 
Decoding mammalian ribosome-mRNA states by translational GTPase complexes. 
Ubiquilins chaperone and triage mitochondrial membrane proteins for degradation. 
Target selection during protein quality control. 
Structural basis for stop codon recognition in eukaryotes. 
Structure and assembly pathway of the ribosome quality control complex. 
Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors. 
Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation. The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay.
Witkin KL, Chong Y, Shao S, Webster MT, Lahiri S, Walters AD, Lee B, Koh JL, Prinz WA, Andrews BJ, and Cohen-Fix O. (2012) PMID: 22658600.
A calmodulin-dependent translocation pathway for small secretory proteins. 
Membrane protein insertion at the endoplasmic reticulum. Tracking F plasmid TraI relaxase processing reactions provides insight into F plasmid transfer.
Dostál L, Shao S, and Schildbach JF. (2011) PMID: 21109533.