Publications

*equal contribution ^#co-corresponding author Shao lab members

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling.
Zhou C, Zhang M, Murray J, Paulo J, Gygi S, Shao S, Whitman M^#, and Keller T^#. (2025) PMID: 41037622.

Visions of the future of molecular cell biology.
Abu-Remaileh M^#, Chan CJ^#, Chen L^#, Demirer GS^#, Fiszbein A^#, Jug F^#, Lechuga-Vieco AV^#, Luisier R^#, Pagan J^#, Sabari BR^#, Shao S^#, Sun L^#, and Zylicz JJ^#. (2025) PMID: 40983749.

Structure of the TXNL1-bound proteasome.
Gao J*, Nardone C*, Yip MCJ*, Chino H, Gu X, Mirman Z, Rale MJ, Paulo JA, Elledge SJ^#, and Shao S^#. (2025) PMID: 40770113. preprint doi: 10.1101/2024.11.08.622741.

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Nardone C*, Gao J*, Seo H, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi N, Fulciniti M, Greenberg ME, Shao S^#, Elledge SJ^#, and Gu X^#. (2025) PMID: 40532701. preprint doi: 10.1101/2025.02.22.639686. PMID: 40027645.

Structures of human organellar SPFH protein complexes.
Gao J, Sherpa D, Kupko N, and Shao S. (2025) preprint doi: 10.1101/2025.04.21.649849.

ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
McKenna MJ, Kraus F, Coelho JPL, Vasandani M, Zhang J, Adams BM, Paulo J, Harper JW, and Shao S. (2025) PMID: 40203102.

Mechanism of ASF1 engagement by CDAN1.
Sedor SF and Shao S. (2025) PMID: 40091041. preprint doi: 10.1101/2024.08.08.607204. PMID: 39149339.

Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation.
Bridgers JB*, Carlström A*, Sherpa D*, Couvillion MT, Rovšnik U, Gao J, Wan B, Shao S^#, Ott M^#, and Churchman LS^#. (2025) preprint doi: 10.1101/2025.01.26.634913. PMID: 39896557.

A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion.
Richmond-Buccola D, Hobbs SJ, Garcia JM, Toyoda H, Gao J, Shao S, Lee ASY, and Kranzusch PJ. (2024) PMID: 38917809.

The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center.
Coelho JPL*, Yip MCJ*, Oltion K, Taunton J, and Shao S. (2024) PMID: 38172604.

The endoplasmic reticulum and the fidelity of nascent protein localization.
McKenna MJ and Shao S. (2023) PMID: 36041782.

Protein biosynthesis at the ER: finding the right accessories.
Shao S. (2023) PMID: 36520029.

ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.
McKenna MJ, Adams BM, Chu V, Paulo JA, and Shao S. (2022) PMID: 36283413.

Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes.
Juette MF*, Carelli JD*, Rundlet EJ*, Brown A, Shao S, Ferguson A, Wasserman MR, Holm M, Taunton J^#, and Blanchard SC^#. (2022) PMID: 36264623.

Mechanism of client selection by the protein quality control factor UBE2O.
Yip MCJ*, Sedor SF*, and Shao S. (2022) PMID: 35915257.

Cryo-EM structure of an active bacterial TIR-STING filament complex.
Morehouse BR, Yip MCJ, Keszei AFA, McNamara-Bordewick NK, Shao S^#, and Kranzusch PJ^#. (2022) PMID: 35869168.

A 'NAC' for targeting proteins to the ER.
Coelho JPL and Shao S. (2022) PMID: 35501234.

Structural insights into metazoan pretargeting GET complexes.
Keszei AFA, Yip MCJ, Hsieh TC, and Shao S. (2021) PMID: 34887561.

Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.
Tal N*, Morehouse BR*, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ^#, and Sorek R^#. (2021) PMID: 34644530.

Selective destabilization of polypeptides synthesized from NMD-targeted transcripts.
Chu V, Feng Q, Lim Y, and Shao S. (2021) PMID: 34586879.

Discovery of C13-aminobenzoyl cycloheximide derivatives that potently inhibit translation elongation.
Koga Y, Hoang EM, Park Y, Keszei AFA, Murray J, Shao S^#, and Liau BB^#. (2021) PMID: 34403584.

Detecting and rescuing stalled ribosomes.
Yip MCJ and Shao S. (2021) PMID: 33966939.

The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.
McKenna MJ*, Sim SI*, Ordureau A, Wei L, Harper JW, Shao S^#, and Park E^#. (2020) PMID: 32973005.

STING cyclic dinucleotide sensing originated in bacteria.
Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, and Kranzusch PJ. (2020) PMID: 32877915.

CBASS immunity uses CARF-related effectors to sense 3'-5'- and 2'-5'-linked cyclic oligonucleotide signals and protect bacteria from phage infection.
Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, and Kranzusch PJ. (2020) PMID: 32544385.

ELAC1 repairs tRNAs cleaved during ribosome-associated quality control.
Yip MCJ, Savickas S, Gygi SP, and Shao S. (2020) PMID: 32075755.

TTC5 mediates autoregulation of tubulin via mRNA degradation.
Lin Z, Gasic I, Chandrasekaran V, Peters N, Shao S, Mitchison TJ, and Hegde RS. (2020) PMID: 31727855.

Mechanism of ribosome stalling during translation of a poly(A) tail.
Chandrasekaran V*, Juszkiewicz S*, Choi J, Puglisi JD, Brown A, Shao S, Ramakrishnan V, and Hegde RS. (2019) PMID: 31768042.

Mechanism for recycling tRNAs on stalled ribosomes.
Yip MCJ, Keszei AFA, Feng Q, Chu V, McKenna MJ, and Shao S. (2019) PMID: 31011209.

Activation of GCN2 by the ribosomal P-stalk.
Inglis AJ, Masson GR, Shao S, Perisic O, McLaughlin SH, Hegde RS, and Williams RL. (2019) PMID: 30804176.

EMC is required to initiate accurate membrane protein topogenesis.
Chitwood PJ, Juszkiewicz S, Guna A, Shao S, and Hegde RS. (2018) PMID: 30415835.

Structures of translationally inactive mammalian ribosomes.
Brown A^#, Baird MR, Yip MCJ, Murray J, and Shao S^#. (2018) PMID: 30355441.

Ribosomes and cryo-EM: a duet.
Brown A^# and Shao S^#. (2018) PMID: 30015201.

In vitro reconstitution of translational arrest pathways.
Feng Q and Shao S. (2018) PMID: 29277545.

Mechanistic basis for a molecular triage reaction.
Shao S, Rodrigo-Brenni MC, Kivlen MH, and Hegde RS. (2017) PMID: 28104892.

Decoding mammalian ribosome-mRNA states by translational GTPase complexes.
Shao S*, Murray J*, Brown A*, Taunton J, Ramakrishnan V, and Hegde RS. (2016) PMID: 27863242.

Ubiquilins chaperone and triage mitochondrial membrane proteins for degradation.
Itakura E, Zavodszky E, Shao S, Wohlever ML, Keenan RJ, and Hegde RS. (2016) PMID: 27345149.

Target selection during protein quality control.
Shao S^#and Hegde RS^#. (2016) PMID: 26628391.

Structural basis for stop codon recognition in eukaryotes.
Brown A*, Shao S*, Murray J, Hegde RS, and Ramakrishnan V. (2015) PMID: 26245381.

The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.
Von der Malsburg K, Shao S, and Hegde RS. (2015) PMID: 25877867.

Structure and assembly pathway of the ribosome quality control complex.
Shao S, Brown A, Santhanam B, and Hegde RS. (2015) PMID: 25578875.

Local synthesis and disposal.
Shao S and Hegde RS. (2014) PMID: 25378608.

Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors.
Shao S and Hegde RS. (2014) PMID: 25132172.

Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation.
Shao S*, von der Malsburg K*, and Hegde RS. (2013) PMID: 23685075.

The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay.
Witkin KL, Chong Y, Shao S, Webster MT, Lahiri S, Walters AD, Lee B, Koh JL, Prinz WA, Andrews BJ, and Cohen-Fix O. (2012) PMID: 22658600.

A calmodulin-dependent translocation pathway for small secretory proteins.
Shao S and Hegde RS. (2011) PMID: 22196732.

Membrane protein insertion at the endoplasmic reticulum.
Shao S and Hegde RS. (2011) PMID: 21801011.

A flip turn for membrane protein insertion.
Shao S and Hegde RS. (2011) PMID: 21729778.

Tracking F plasmid TraI relaxase processing reactions provides insight into F plasmid transfer.
Dostál L, Shao S, and Schildbach JF. (2011) PMID: 21109533.